The Seattle Seahawks entered Week 16 in second place in the NFC West and as the No. 5 seed and exited with the division lead and control of the coveted No. 1 seed. While the easiest way for the Seahawks to confirm their home-field advantage throughout the playoffs is to win their remaining two games, […]
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The Indianapolis Colts (8-6) host the San Francisco 49ers (10-4) on primetime (8:15 PM EST) trying to keep their late season playoff hopes alive. Having lost 5 of their last 6 games, it’s desperation time in Indy. Entering the evening, the Colts average the league’s 6th most points (28.0 avg. ppg.) and surrender its 13th […]
Monday Night Football brings an interconference matchup that puts the San Francisco 49ers on the road against the Indianapolis Colts. This game matters for playoff positioning and momentum, and the betting market reflects a competitive but clearly defined matchup. You are looking at a spread under a touchdown, a mid-range total, and moneylines that suggest one team holds the edge but still faces risk away from home.
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The San Francisco 49ers are in the playoffs. Week 16 has been kind to them. There are a couple of outcomes from a seeding perspective, based on how Monday night against the Indianapolis Colts goes. Oddsmakers believe the 49ers are nearly a touchdown better than the Colts. We will see if it plays out that […]
Monday Night Football delivers another exciting game with the 49ers vs Colts battling for playoff positioning. Both teams boast good lineups that offer numerous NFL DFS options on BN Fantasy . The 49ers have one of the league’s most dangerous players in Christian McCaffrey. Meanwhile, the Colts will lean on their own star runner, Jonathan Taylor with Philip Rivers making his 2nd start.
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Indianapolis, IN — The Indianapolis Colts have received a big-time reinforcement ahead of their Monday Night Football matchup against the San Francisco 49ers. Star defensive tackle DeForest Buckner (neck) has officially been activated from the injured reserve list after missing the last five games, a fitting return to the limelight as this is Indy’s first […]
With the San Francisco 49ers winning their last four games against what may be the easiest stretch of their schedule, they turn around to begin the toughest stretch of their schedule with a Monday night tilt against the Indianapolis Colts. A few weeks ago, this game against Indianapolis was trending towards being a matchup between […]
The wildest storyline of the NFL season continues tonight as 44-year-old quarterback Philip Rivers will start at quarterback for the second straight week for the Colts. Check out his passing props and odds for tonight’s Monday Night Football game between the 49ers and Colts.
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Philip Rivers Passing Props
(Rivers played his first game since 2020 last week. Photo: Kevin Ng-Imagn Images)
The Colts shocked the world last week when they...
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The San Francisco 49ers travel to Naptown to take on the Indianapolis Colts. One team is surging and playing for the No. 1 seed, while the other is fighting for its playoff hopes. The Niners are going to get the Colts’ best punch on Monday night. It’s a game Indy needs, so expect Shane Steichen […]
The Jacksonville Jaguars (11-4) will fly from the Rocky Mountains to the Midwest to face the Indianapolis Colts (8-6 at the time of this writing) at 1:00 p.m. EST on Sunday, Dec. 28. According to FanDuel Sportsbook, the Jaguars are 6.5-point favorites and the total is set at 45.5 points. The Colts play tonight on […]
The Los Angeles Chargers are coming off a big win against Dak Prescott and the Dallas Cowboys in Week 16, getting one step closer to a playoff berth. The Chargers can officially clinch a playoff spot if the San Francisco 49ers beat the Indianapolis Colts on Monday Night Football, but they will also do so […]
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At 7-1, the Indianapolis Colts were in firm control, not only of the AFC South but of the entire AFC. A tie breaker win over the Denver Broncos provided that much more room to breathe. Things were smooth sailing until they weren’t. With four straight losses and five out of six dropped, the Colts no […]
49ers lock up a playoff berth in wake of Lions’ loss to Pittsburgh (paywall)“The 49ers secured a playoff berth on Sunday when the Lions lost to the Steelers, 29-24, assuring San Francisco of reaching the postseason after a one-season absence.” Five 49ers players to keep an eye on in prime-time Week 16 game vs. Colts“Although […]
The Indianapolis Colts announced on Sunday that starting left tackle Bernhard Raimann (elbow) has been downgraded from questionable to out for Monday Night football’s home game against the San Francisco 49ers. Raimann was able to practice on a limited basis on Saturday for the first time all week, with an arm brace on his injured […]
The San Francisco 49ers (10-4) bring a four-game winning streak into a matchup against the Indianapolis Colts (8-6) on Monday, December 22, 2025 at Lucas Oil Stadium. San Francisco is a 5.5-point favorite in the contest. The over/under is set at 46 points for the outing.
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How to watch 49ers vs. Colts: TV channel & live stream
TV channel: ESPN
49ers Insights
The 49ers’ offen...
The San Francisco 49ers (10-4) will be monitoring three players on their injury report going into a Monday, Dec. 22 game against the Indianapolis Colts (8-6) at Lucas Oil Stadium, due to start at 8:15 p.m. ET. The Colts currently have five players listed on their report.
How to Watch 49ers vs. Colts
Game date: Monday, December 22, 2025
Time: 8:15 p.m. ET
Venue: Lucas Oil Stadium
Location: Indianapolis, Indiana
TV: ESPN
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The Indianapolis Colts (8-6) will have their eyes set on rebounding from their four-game losing streak when they take on the San Francisco 49ers (10-4) at Lucas Oil Stadium on Monday, December 22, 2025.
49ers vs. Colts Odds
Point Spread
The spread for this matchup is set at 5.5 points, with sportsbooks listing the 49ers as the favorites.
Moneyline
As for the moneyline, the 49ers have -258 odds to pick up the win, while the Colts are listed at +209 to claim victory.
Over/Under
Fin...
San Francisco 49ers tight end Jake Tonges will match up with the 31st-ranked passing defense of the Indianapolis Colts (247.6 yards allowed per game) in Week 16, at 8:15 p.m. ET on Monday.
With his upcoming matchup against the Colts this week, should Tonges be considered a lock for your fantasy football lineup? We dissect the stats and trends below.
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Jake Tonges Week 16 Game Info
Let’s highlight a few of the...
Kendrick Bourne and the San Francisco 49ers will play the Indianapolis Colts and their 31st-ranked passing defense (247.6 yards conceded per game) in Week 16, on Monday at 8:15 p.m. ET.
With his upcoming game versus the Colts this week, should Bourne be considered a lock for your fantasy football lineup? We dissect the stats and trends below.
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Kendrick Bourne Week 16 Game Info
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In Week 16 (Monday at 8:15 p.m. ET), wide receiver Demarcus Robinson and the San Francisco 49ers will meet the Indianapolis Colts, who have the 31st-ranked passing defense in the NFL (247.6 yards allowed per game).
Is Robinson’s game against the Colts this week a good time to start him in fantasy? Below, we highlight his relevant fantasy statistics.
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Demarcus Robinson Week 16 Game Info
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The San Francisco 49ers are inching closer and closer to a playoff berth, getting the chance to clinch their spot in the postseason with a win over the Indianapolis Colts on Monday Night Football in Week 16. To do so, they’ll have to get through Jonathan Taylor, who has been the NFL’s best running back […]
49ers’ Ricky Pearsall out for Monday’s game at Colts with knee injury (paywall)“Kyle Shanahan said Pearsall came close to playing versus the Colts. But he didn’t practice this week and was limited to sprinting on a side field during Friday’s session. “He was close, but not close enough,” Shanahan said.“ 49ers vs. Colts: The Standard’s […]