San Francisco 49ers QB Brock Purdy will match up with the 21st-ranked pass defense of the Arizona Cardinals (225.3 yards allowed per game) in Week 11, at 4:05 p.m. ET on Sunday.
When setting your fantasy football lineup this week, is Purdy worth inserting into your starting lineup? For insights into his matchup versus the Cardinals, we’ve got you covered.
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Brock Purdy Week 11 Game Info
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From Bleacher Nation | Chicago Sports News, Rumors, and a Reasonable Level of Obsession
| 23 days ago
| 3 reads
The San Francisco 49ers suffered a huge blow to their defense a few weeks ago when Fred Warner was ruled out with a season-ending ankle injury. It was a crushing blow, given that the 49ers had already lost defensive end Nick Bosa for the season, as San Francisco was hoping to have its stars bridge […]
From Niners Nation
| 23 days ago
| 2 reads
The San Francisco 49ers are getting some much-needed reinforcements this week, as starting quarterback Brock Purdy and wide receiver Ricky Pearsall are both returning from multi-week injuries. Purdy has been out since Week 4 after re-aggravating a toe injury, while Pearsall has missed the same amount of time with a knee injury. For Pearsall, the […]
From Niners Nation
| 24 days ago
| 2 reads
The San Francisco 49ers started it all. It’s their fault. In Weeks 1 and 2, the Arizona Cardinals defeated the New Orleans Saints and the Carolina Panthers to begin this season 2-0-0. Their next contest was on the road against the 49ers. RELATED: CARDINALS OPEN AS HOME UNDERDOGS In the fourth quarter, the score was […]
From Revenge of the Birds
| 24 days ago
| 2 reads
As the season slowly goes into November, the Arizona Cardinals are close to playing for one thing… pride. That is never a good thing when you are talk about the third year of a rebuild, but things have gone off the rails and who knows if they can get back on them. Ahead of their […]
From Revenge of the Birds
| 24 days ago
| 3 reads
Kyle Shanahan reveals Brock Purdy will start 49ers’ Week 11 game vs. Cardinals“That’s why we were really close to getting him up last week, but still thought it would help him for another week, and so did he,” Shanahan said. “The way he was Monday, just watching him film with him, the way he was […]
From Niners Nation
| 24 days ago
| 3 reads
The San Francisco 49ers (6-4) hit the road for a NFC West clash against the Arizona Cardinals (3-6) on Sunday, November 16, 2025 at State Farm Stadium.
The 49ers are averaging 22.0 points per game on offense this year (23rd in NFL), and they are surrendering 23.0 points per game (15th) on the defensive side of the ball. The Cardinals are compiling 22.4 points per contest on offense this season (20th-ranked). Meanwhile, they are surrendering 23.9 points per contest (19th-ranked) on defense.
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From Bleacher Nation | Chicago Sports News, Rumors, and a Reasonable Level of Obsession
| 24 days ago
| 3 reads
It’s official. San Francisco 49ers quarterback Brock Purdy will make his return to the starting lineup this Sunday against the Arizona Cardinals, per Kyle Shanahan. On Wednesday, Shanahan said, “I think each week it’s gotten better, with last week being the best. Each week has been different. So, if he takes a big step forward […]
From Niners Nation
| 24 days ago
| 2 reads
I know. The headline is a very big-brained idea for the San Francisco 49ers and Kyle Shanahan. The player who leads the world in touches should be the focal point for the 49ers’ offense in Arizona on Sunday. Hear me out, this is exactly the type of game and matchup Christian McCaffrey is built for. […]
From Niners Nation
| 24 days ago
| 3 reads
Welcome to SB Nation Reacts, a survey of fans across the NFL. Throughout the year, we ask questions of the most plugged-in 49ers fans and fans across the country. Sign up here to participate in the weekly emailed surveys. The San Francisco 49ers have tweaked their lineup on both sides of the ball through 10 […]
From Niners Nation
| 24 days ago
| 2 reads
Welcome to SB Nation Reacts, a survey of fans across the NFL. Throughout the year we ask questions of the most plugged-in 49ers fans and fans across the country. Sign up here to participate in the weekly emailed surveys. Heading into Week 11, we want to know how you’re feeling after watching the team so […]
From Niners Nation
| 24 days ago
| 2 reads
With another divisional game on tap for the San Francisco 49ers, the Kyle Shanahan-led group will look to bounce back with its fourth NFC West victory over Arizona on Sunday. The undermanned 49ers defense took a beating against the Rams and their MVP candidate, Matthew Stafford, last Sunday, but it only counts as one loss. […]
From Niners Nation
| 24 days ago
| 3 reads
San Francisco 49ers wide receiver Brandon Aiyuk was eligible to return in Week 5. There was cautious optimism that it would happen after preseason videos surfaced of Aiyuk running routes at about 25 percent. That was in August. The assumption was that, by late October, Aiyuk would be up to speed and ready to play […]
From Niners Nation
| 24 days ago
| 2 reads
As the title suggests, I could simply copy and paste what I have written in these write-ups from previous weeks. For the third consecutive week, quarterback Matthew Stafford threw four or more touchdowns in a game, a first in NFL history. This past Sunday against the San Francisco 49ers, the MVP of the 2009 Capital […]
From Dawg Sports
| 24 days ago
| 2 reads
There is no doubt that when it comes to the Los Angeles Rams, the benchmark for fans is always, “be better than the 49ers.” When it comes to rivalries in the NFL, Rams-49ers is certainly right near the top with Cowboys-Eagles, Browns-Steelers, and Packers-Bears. These are two teams that have played 154 times and reached […]
From Turf Show Times
| 24 days ago
| 3 reads
The San Francisco 49ers are sitting at 6-4 heading into Week 11, as they prepare to take on the Arizona Cardinals on the road in a big game. The 49ers are coming off an ugly 42-26 loss to the Los Angeles Rams, where they took themselves out of it early by allowing three consecutive touchdown […]
From Niners Nation
| 24 days ago
| 3 reads
The San Francisco 49ers are currently trending to start quarterback Brock Purdy for the first time since Week 4 this weekend when they face the Arizona Cardinals on the road. Purdy, who has been limited in practice for the last few weeks as he’s ramped up following a toe injury, has now had one ‘aggressive’ […]
From Niners Nation
| 25 days ago
| 2 reads
Kyle Shanahan previews 49ers-Cardinals Week 11 matchup“”Not on Thursdays. We have to by a certain time. I think we’re allowed 15, so I think we always stop then. A lot of times on Thursdays we’ll get two periods in and take them off the second two. Most of the time, it depends on who I […]
From Niners Nation
| 25 days ago
| 2 reads
49ers News Purdy Targets Cardinals Return After Six-Week Absence San Francisco quarterback Brock Purdy will practice aggressively on Wednesday as the 49ers prepare him to start Sunday against Arizona. Head coach Kyle Shanahan said Purdy’s workload will increase significantly this week. The quarterback has been a limited participant in recent practices but hasn’t appeared in […]
From Gridiron Experts
| 25 days ago
| 2 reads
The San Francisco 49ers will have Brock Purdy and Ricky Pearsall practicing in some capacity on Wednesday. Those two, along with Alfred Collins (hip) and Dee Winters (knees) will be limited during Wednesday’s session. Shanahan said this will be an aggressive practice for Purdy, despite his status on the injury report: “We just got to […]
From Niners Nation
| 25 days ago
| 1 read
The San Francisco 49ers were rather quiet in free agency this offseason, letting several veterans walk, while not signing any player to a deal worth more than $5.25 million per year. Instead, the goal was to rely on and develop the team’s younger talent as they cleaned the books in what seemed like a ‘bridge’ […]
From Niners Nation
| 25 days ago
| 1 read
Many fans have been wondering when the San Francisco 49ers will see what they have in rookie third-round pick Nick Martin. After all, this is a defense that has struggled mightily since Fred Warner dislocated his ankle a month ago. For much of the season, Martin was a healthy scratch. Martin’s season debut came in […]
From Niners Nation
| 25 days ago
| 1 read
The Arizona Cardinals won’t have their top wide receiver, Marvin Harrison Jr., in Week 11. The second-year pro had surgery for appendicitis, which will keep him out of a home game against the San Francisco 49ers this week. Harrison Jr. is second on the Cardinals in targets, receptions, yards, and touchdowns, behind tight end Trey […]
From Niners Nation
| 25 days ago
| 1 read
The 49ers’ decision not to make a swing for a pass rusher on trade deadline day last week raised some eyebrows, with San Francisco unwilling to pay a premium to boost a defensive line clearly in desperate need of help. Last Sunday’s 42-26 defeat to the Los Angeles Rams served as an illustration of why, […]
From Niners Nation
| 25 days ago
| 1 read
It’s usually doom and gloom after a loss. The finger-pointing among fans is non-stop, the playoffs shouldn’t be discussed, and somebody needs to be fired. Heading into Week 11, the San Francisco 49ers are on the outside looking in of the NFC playoff picture and sit third in the NFC West standings. Let’s ignore the […]
From Niners Nation
| 26 days ago
| 2 reads